Niacinamide, also known as nicotinamide or Vitamin B3 has acquired a whole lot of consideration in the world of skin treatment in the previous few of months. This ingredient was a short while ago showcased as a very promising anti-ageing option on the Dr. Oz Present and this has instantly sparked conversations throughout the world wide web.By now, we’ve all read about the excellent advantages of Vitamin B3 in all sorts of products ranging from anti-aging lotions to skin whitening remedies. But, in the midst of all these promises, how can a person be positive of what is true and what is, properly… just rumour?

In the subsequent couple of paragraphs, we are going to evaluation with each other the scientific evidence that backs some of these claims but initially let us get started with a swift introduction to niacinamide.

What is niacinamide and what does it do?

Niacinamide is part of the team B of nutritional vitamins and is also from time to time identified as vitamin B3. Vitamin B3 also exists in another huge unfold sort named niacin which is transformed to niacinamide inside the body. Both equally forms of vitamin B3 effectively have the similar rewards but niacin is nicely identified for inducing disagreeable but harmless side consequences these as flushing and warming of the skin. To steer clear of these, most skin care items are formulated with niacinamide which offers the very same skin added benefits but none of the side consequences. The major operate of niacinamide inside the system is to be a precursor of the coenzymes NAD and NADP. A precursor only usually means a creating block that the entire body makes use of to make other, usually greater and a lot more useful compounds. NAD stands for Nicotinamide Adenine Dinucleotide and is an extremely vital coenzyme in all living cells and, like its close relative NADP, is associated in critical cellular functions.

But how accurately does it support your skin and is it really the treatment-all style of component that it is manufactured to seem like? Nicely the reply is indeed… to some extent. Just one certain detail is that Niacinamide is one of the most researched substances in the pores and skin care marketplace, undoubtedly a lot more so than other folks that are typically applied. But let’s see what science says about the most common niacinamide claims we have all read about.

Declare 1: Niacinamide can lighten and proper pores and skin tone. Scientific Proof: Very Powerful.

The proof we have so considerably that niacinamide can lighten and unify pores and skin tone is quite solid and supported by dozens of impartial scientists. The most current publication on the matter, which appeared very last thirty day period in the Pores and skin Study Technological innovation Journal, found that niacinamide diminished the visual appeal of hyperpigmentation in a review on 42 Korean Ladies right after 8 weeks of use (Lee et al. 2014). For people who may well not be acquainted with the expression, hyperpigmentation is a health-related name for spots or spots on your skin that are darker than the relaxation, these types of as for instance age spots. In 2013, a further article confirmed that a 4% niacinamide products lessened axillar hyperpigmentation in a similar review done on 24 gals for a period of time of 9 weeks (Castanedo-Cazares et al. 2013). And in the past two many years, there are at minimum a dozen other articles with extremely very similar conclusions which would be cumbersome to checklist. However, a single posting warrants mention. In 2011, a incredibly important analyze confirmed that niacinamide does not only lessen hyperpigmentation, but that its results are equivalent to these of hydroquinone (Castanedo-Cázares JP et al. 2011). Now, hydroquinone is classically extremely successful at eradicating dark places, but its facet consequences can be horrendous in some people, so much so that the Fda not too long ago proposed an in depth investigation of hydroquinone major to a probable removing from around the counter products in the foreseeable future.

Claim 2: Niacinamide can help with pimples. Scientific proof: Quite Strong.

There are more than 2 dozen articles in peer-reviewed journals that have examined the usefulness of niacinamide in the treatment method of acne. The most improvement to day seems to arise in folks with light-weight to reasonable acne and the rationale looks to be two fold. On a person hand, niacinamide can decrease facial sebum output (Draelos et al. 2006). At the exact same time, it also inhibits skin irritation about zits major to fewer and fewer extreme red places (Fivenson DP 2006). Having said that the circumstance might be, what is important is that niacinamide fares amazingly well when compared to a typical pimples treatment. Indeed, a the latest study confirmed that topical niacinamide versus clindamycin, a prescription antibiotic, lead to the very same advancement level in 40 patients with reasonable pimples (Khodaeiani et al. 2013). That is the strongest proof so considerably that implies that niacinamide may potentially be as superior as some other common prescription therapies for zits.

Assert 3: Niacinamide can tighten and carry sagging skin. Scientific evidence: Weak to Moderate.

Even though a sizeable amount of scientific tests have examined the effect of niacinamide on wrinkles (see declare underneath) and on other international anti-growing older signs, quite number of have seemed at the effects on sagging skin. Just one way to measure improvements in drooping skin is to glance at modifications in pores and skin elasticity. A person these kinds of examine published a 10 years in the past found that beside bettering pores and skin sallowness, wrinkles and fine lines, niacinamide also enhanced skin elasticity in a sample of 50 ladies (Bissett DL et al. 2005). Now, we know that niacinamide enhances the barrier function of pores and skin and stops loss of drinking water, so this observed raise in elasticity may perhaps just be a aspect result of its strong moisturizing capabilities. Although the info is encouraging so considerably, additional study is however needed to recognize the consequences of niacinamide on skin elasticity.

Claim 4: Niacinamide can reduce wrinkles. Scientific proof: Strong.

The fact that niacinamide increases the physical appearance of wrinkles and great lines is supported by numerous experiments about the yrs. The most latest and also arguably a single of the most vital was released by JJ FU and colleagues in 2010. The authors when compared a cosmetic product made up of niacinamide in conjunction with peptides and retinol from the drug Tretinoin. For those people who may not be acquainted with this drug, Tretinoin is an acid spinoff of retinol, in other phrases a compound that can be acquired from retinol just after a chemical modification. Tretinoin is Food and drug administration approved for the treatment method of wrinkles and can only be acquired by means of healthcare prescription. Thus it represented the ideal benchmark for this analyze. So how effectively did the program that contains niacinamide fare in opposition to Tretinoin? Exceptionally nicely. As it turns out, the therapy containing niacinamide, peptides and retinol surpassed Tretinoin just after 8 weeks, nonetheless this variation diminished later and equally regimens guide to comparable improvements at the stop of the examine after 24 weeks (Fu JJ et al. 2010). To best it all off, topics tolerated (i.e. experienced fewer aspect effects) the non prescription formulation considerably much better than the prescription drug.

Declare 5: Niacinamide can tighten pores. Scientific Evidence: Weak.

Despite the fact that niacinamide might support lower the visual appearance of pimples (see assert 2), there is absolutely nothing to reveal that the visual appeal of regular pores, i.e. non-infected by a zit, can be shrunk by the use of niacinamide. The use of conventional astringents is however the greatest cure in this situation. This assert looks to have arisen from largely anecdotal accounts, which does not indicate it is not correct it only signifies that it is not supported by science… nevertheless.

These are some of the most widespread hypes about niacinamide. Some say it is a wonder ingredient, some believe it is a marketing and advertising trend. In the long run, the scientific proof overwhelmingly suggests that niacinamide could be, in most situations, a single of the most important ingredients to appear for in a pores and skin care program.


  1. Reduction in facial hyperpigmentation right after cure with a mix of topical niacinamide and tranexamic acid: a randomized, double-blind, auto-controlled trial. Lee do H, Oh IY, Koo KT, Suk JM, Jung SW, Park JO, Kim BJ, Choi YM. Pores and skin Res Technol. 2014 Could20(2):208-12. doi: 10.1111/srt.12107.
  2. Topical niacinamide 4% and desonide .05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled review. Castanedo-Cazares JP, Lárraga-Piñones G, Ehnis-Pérez A, Fuentes-Ahumada C, Oros-Ovalle C, Smoller BR, Torres-Álvarez B. Clin Cosmet Investig Dermatol. 20136:29-36. doi: 10.2147/CCID.S39246.
  3. A Double-Blind, Randomized Medical Trial of Niacinamide 4% vs . Hydroquinone 4% in the Treatment of Melasma. Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, Martínez-Ramírez JD, Moncada B. Dermatol Res Pract. 20112011:379173. doi: 10.1155/2011/379173.
  4. The effect of 2% niacinamide on facial sebum production. Draelos ZD, Matsubara A, Smiles K. J Cosmet Laser Ther. 2006 Jun8(2):96-101.
  5. The mechanisms of motion of nicotinamide and zinc in inflammatory skin disease. Fivenson DP. Cutis. 2006 Jan77(1 Suppl):5-10. Review.
  6. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER. Int J Dermatol. 2013 Aug52(8):999-1004. doi: 10.1111/ijd.12002.
  7. Niacinamide: A B vitamin that increases getting older facial skin visual appeal. Bissett DL, Rectangular JE, Berge CA. Dermatol Surg. 2005 Jul.
  8. A randomized, managed comparative review of the wrinkle reduction added benefits of a beauty niacinamide/peptide/retinyl propionate item program vs. a prescription .02% tretinoin product or service regimen. Fu JJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR. Br J Dermatol. 2010 Mar162(3):647-54.